Whenever i pick my 335 up for a jam i always play the blues. i love the sound of that minor pentatonic scale. Sad and mournful. You don’t play the blues. You feel the blues! Playing the notes is one thing but its the subtle techniques of vibrato, slides, micro and quarter bends that bring the notes to life.
An important thing to remember is that speed is of no importance in the blues. Sure it may impress your buddies but after a few minutes everyone will be bored. Some of the best blues players actually don’t play quick at all, Muddy Waters and John Lee Hooker are two examples of true bluesmen with great feel and soul where a few notes on the guitar is all that’s needed.
Tone is also very important. I like plugging my Gibson 335 straight into my Fender Deluxe Reverb and letting that bird sing. Get myself a beer and i’m halfway to heaven!